FLC OF AN MLG INADVERTENTLY LINED UP AND STARTED TKOF ON THE WRONG RWY AT CLE. ANOTHER ACFT FLC GAVE WARNING TO RPTING CREW RESULTING IN THE TWR CANCELING TKOF CLRNC WHEREIN THE TKOF WAS ABORTED.

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ABORT DUE WRONG RWY FOR TKOF. LOCATION; CLE HOPKINS. CREW OF ACR X WAS CLRED FOR TKOF RWY 23L AND INADVERTENTLY LINED THE ACFT UP FOR RWY 28. WHEN PWR WAS ADDED FOR TKOF; WE IMMEDIATELY REALIZED THAT WE WERE ON THE WRONG RWY AND ABORTED AND ADVISED THE TWR. TWR CLRED US FOR A 180 DEG TURN AND WE RECHKED OUR CHKLIST AND MADE A TKOF ON RWY 23L WHEN CLRED. SUPPLEMENTAL INFO FROM ACN 329661: CLEVELAND ARPT LAYOUT IS CONDUCIVE TO RWY INCURSIONS. WE OBSERVED AN MD80 TAXI ONTO RWY 28 TO ACCESS THE ACTIVE RWY 23L. THE NE CORNER OF THIS ARPT IS VERY 'BUSY' WITH NUMEROUS RWY/TXWY INTXNS. TWR CLRED ACR X FOR TKOF ON RWY 23L AND ACR X STARTED HIS TKOF ROLL ON RWY 28. AN ALERT ACR Y; A JET BEHIND BROADCAST SEVERAL RAPID WARNINGS THAT ACR X WAS TAKING OFF ON THE WRONG RWY. FINALLY TWR CANCELED ACR X CLRNC AND HE ABORTED. ACR X WAS GOING TO MIA AND ONLY 5000 FT WAS AVAILABLE FROM WHERE HE STARTED HIS ROLL. THIS AREA AT CLE IS VERY CONFUSING. CLE HAS PROPER SIGNAGE; BUT SOME FEDERAL DOLLARS SHOULD BE SPENT TO REVISE THIS NE CORNER INTO A SAFER OP; IE; ONE WHERE TAXI ON RWYS TO ACCESS OTHER RWYS IS NOT REQUIRED.