FO OF A DC9-30 FAILED TO TURN OVER A XING FIX PER FLT PLAN RESULTING IN ATC INTERVENTION TO REMIND THE CREW OF THEIR FLT PLAN ROUTING.

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CLRNC TO ACY WAS DIRECT DQO DIRECT ENO DIRECT SIE DIRECT ACY. NORMAL CLRNC IS TO CROSS DQO AT 13000 FT; ASSIGNED ALT THIS DAY WAS 14000 FT. UPON REACHING DQO (FO FLYING) CREW FAILED TO NOTE STATION XING AND FAILED TO TURN TOWARD ENO. CTR CTLR ASKED IF WE WERE GOING TO TURN AS THERE WAS TFC IN FRONT OF US. CREW IMMEDIATELY INITIATED TURN AND THEN WAS GIVEN VECTOR. TFC WAS NOT A FACTOR AT TIME ACFT WAS TURNED BACK ON COURSE; HOWEVER IT COULD HAVE BEEN IF CTLR HAD NOT BEEN ALERT. TO MY KNOWLEDGE NO ALERTS WERE ISSUED; TCASII OR CTLR. I BELIEVE THAT THIS INCIDENT WAS CAUSED BY CREW FATIGUE CAUSED BY BEING ON 24 HR RESERVE. CREW WAS CALLED IN AT XA00 TO RELIEVE A CREW THAT WAS ABOUT TO EXCEED THE REQUIREMENTS OF FAR 121.471(B) (1). CREW DEPARTED ACY AT XE00 TO PIT ARRIVING AT HOTEL AT XF30; DEPARTED HOTEL AT XK00 FOR XL25 SCHEDULED DEP TO ACY. THIS LEAVES LIMITED TIME FOR REST. THE FARS ALLOW CARRIERS TO ASSIGN CREWS TO 24 HR RESERVE UP TO 6 CONSECUTIVE DAYS. DURING THIS TIME THE CREW MEMBER MAY BE CALLED TO FLY WITH MINIMAL NOTICE. 1 HR TO SHOW AT ARPT IS COMMON. WHEN ARE THESE CREWS SUPPOSED TO REST? ONCE CALLED THESE CREWS CAN BE ON DUTY FOR 16 HRS AND FLY UP TO 8 HRS. OTHER FACTORS INCLUDE: THIS WAS FIRST TIME THIS CREW FLEW TOGETHER. FO'S LOW TIME IN TYPE. NORMAL XING RESTR CHANGED. FAILURE OF CAPT TO ADEQUATELY MONITOR FO.