MD88 CREW HAD A RWY INCURSION OF RWY 4-22 AT HOU.

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DURING TAXI FOR TKOF FOR RAMP VIA TXWY D AND G TO RWY 4 (ACTIVE); PLTS BECAME CONFUSED AND MISTOOK RWY 17/35 AS RWY 4/22 SUBSEQUENTLY XING THE APCH END OF RWY 4/22 ON TXWY G. SIGNAGE PRIOR TO THE APCH/HOLD SHORT LINE FOR RWY 4 ON TXWY G INDICATED BOTH RWY 17/35 AND 4/22 WHICH DID NOT CLEAR UP ON CORRECTING THE CONFUSION. FLT WAS ABLE TO TURN AROUND AT RWY 35 RUN-UP PAD AND RETURN FOR TKOF RWY 4 VIA TXWY G PER TWR INSTRUCTIONS. RECOMMEND A SIGNAGE CHANGE ON TXWY G WHEN APCHING RWY 4 FROM THE N ON G TO CLEAR-UP ANY CONFUSION. CALLBACK CONVERSATION WITH RPTR REVEALED THE FOLLOWING INFO: THE CAPT CALLED THE TWR SUPVR AFTER LNDG. IN DISCUSSION WITH HIM HE INDICATES THAT THIS IS A PROB AREA ON THE ARPT. MANY OTHER ACFT HAVE HAD RWY INCURSIONS AT THIS POINT. THE RPTR STATES BOTH CREW MEMBERS HAD THE ARPT PLATE PAGE OUT FOR REFERENCE; AND THEY WERE STILL CONFUSED AS TO THEIR EXACT LOCATION IN RELATION TO THE CLEARED RWY. HE SAID THERE IS A LOT GOING ON AT THIS TIME; IN THE COCKPIT. CHKLISTS; TALKING TO TWR; AND ADVISING THE FA THAT TKOF IS ABOUT TO OCCUR.