BE40 EXPRESSED CONCERN WITH CONFLICTING DEP ACFT AFTER GND CTL ISSUED RWY XING CLRNC AT HOU.

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WE WERE PARKED ON THE ESE SIDE OF THE HOUSTON HOBBY ARPT. WE CALLED FOR TAXI AND RECEIVED THE FOLLOWING CLRNC. 'NXX; TAXI TO RWY 12R VIA TXWYS C; Z; E.' WE READ BACK FULL INSTRUCTIONS. WE PROCEEDED TO TXWY C AND BEFORE TURNING ONTO TXWY C WE RECEIVED THE FOLLOWING CLRNC; 'NXX; HOLD SHORT OF RWY 22 ON TXWY C.' WE READ BACK FULL HOLD SHORT INSTRUCTIONS. AS WE ARE TAXIING AND APCHING THE HOLD SHORT LINE AT RWY 22 ON TXWY C; WE RECEIVED THE FOLLOWING CLRNC; 'NXX; CROSS RWY 22 AND TAXI VIA TXWYS C; Z; E.' WE READ BACK FULL INSTRUCTIONS. AS PER COMPANY SOP PRIOR TO XING ANY RWY; WE VISUALLY AND AUDIBLY CLR L; CLR R; AND CONFIRM CLRED TO CROSS. AS I WAS CLRING AT ABOUT MY 10 O'CLOCK POS; THERE WAS AN AIRPLANE ON ITS TKOF ROLL IN WHICH I BRAKED IMMEDIATELY; PUTTING ME ON THE HOLD SHORT LINE. I KNEW WE WERE CLRED TO CROSS; BUT I INSTRUCTED MY COPLT TO CONFIRM THAT WE WERE CLRED TO CROSS RWY 22 AND WE RECEIVED AN 'AFFIRMATIVE' FROM GND CTL. WE THEN REPLIED WITH 'WHAT ABOUT THIS AIRPLANE THAT JUST DEPARTED IN FRONT OF US?' THERE WAS NO REPLY. WE THEN PROCEEDED TO CLR THE RWY AND ONCE CONFIRMED CLR; WE CROSSED RWY 4/22 AND TAXIED TO RWY 12R VIA TXWYS C; Z; E WITH CAUTION. OUR NEXT CLRNC FROM THE GND CTLR WAS 'NXX; MONITOR TWR.'