SF340 FLT CREW HEARS WHAT THEY EXPECT TO HEAR WHEN RECEIVING RWY ASSIGNMENT FOR LANDING ON DTW RWY 22R. DURING THE LOC INTERCEPT THE CONTROLLER ADVISES THAT THEY SHOULD BE INTERCEPTING 22L LOC AND ISSUES A HEADING.

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THE CLOSURE OF RWY 21L IN DTW HAS CHANGED THE 'NORMAL' ARR SEQUENCE INTO DTW. RWY 22L IS ALMOST ALWAYS USED FOR TKOF AND SELDOM USED FOR LNDG. THIS I BELIEVE SET US UP TO BELIEVE WE WOULD 'DO WHAT WE ALWAYS DO' THAT IS USE THE RWY 22R APCH AND LAND ON THAT RWY. ALSO THIS OCCURRED AT THE END OF A VERY TIRING PATTERN. MY SCHEDULE HAD BEEN CHANGED BECAUSE I WAS GOING TO BE OVER 30/7. THE CHANGE WAS ABOUT 15 MINS SO I WAS STILL SCHEDULED AT THE MAX ALLOWABLE TIME. THIS WAS THE LAST DAY OF THIS PATTERN. AT THIS TIME I AM STILL NOT SURE THAT IT WAS NOT ATC THAT ISSUED US THE WRONG APCH AS WE (THE FO AND I) BOTH BELIEVE WE ACCEPTED AND READ BACK A CLRNC FOR RWY 22R. WE WERE ON APCH TO RWY 22R WHEN ATC ASKED IF WE WERE CORRECTING FOR THE ILS TO RWY 22L. AT THIS TIME WE WERE APPROX 10-12 MI FROM THE ARPT AND JUST JOINING THE RWY 22R LOC. WE TOLD ATC WE HAD BEEN CLRED FOR RWY 22R AND ATC SAID NO WE HAD BEEN CLRED FOR RWY 22L AND TO STOP DSCNT AND FLY HDG 180 DEGS TO JOIN THE RWY 22L LOC. ATC THEN ISSUED CLRNC FOR RWY 22L AND WE JOINED THAT LOC AND LANDED WITHOUT FURTHER INCIDENT. ATC QUESTIONED IF WE WERE CORRECTING FOR LOC RWY 22L WE REPLIED WE WERE CLRED FOR RWY 22R. ATC THEN GAVE US A HDG TO JOIN RWY 22L. WE STOPPED OUR DSCNT AND TURNED TO THE HDG ATC HAD GIVEN US. SINCE WE WERE STILL 10-12 MI FROM THE ARPT WE HAD TIME TO SET UP FOR THE RWY 22L APCH. WE TUNED AND IDENTED THE CORRECT FREQ AND THE APCH AND LNDG WERE UNEVENTFUL. CLR COM IN TERMINAL AREA IS VERY IMPORTANT. DTW LIKE MOST LARGE ARPTS CAN BE VERY BUSY DURING AN ARR PHASE. FREQ JAMMING IS UNFORTUNATELY A COMMON OCCURRENCE. WE BOTH BELIEVE WE HEARD AN APCH CLRNC GIVEN THAT THE CTLR OBVIOUSLY BELIEVES THEY DID NOT GIVE. IT IS IMPERATIVE WE AND ATC ARE ON THE SAME PAGE EVEN IF IT REQUIRES AN EXTRA RADIO CALL. I BELIEVE THAT FATIGUE PLAYED A PART AS THIS IS A VERY BUSY AND TIRING PATTERN. IT IS 4 DAYS OF ALMOST NONSTOP FLYING WITH FEW BREAKS. THE WELL KNOWN HUMAN FACTORS OF REST ARE ALMOST COMPLETELY IGNORED WITH THIS TYPE OF SCHEDULE.