AN AIR CARRIER PILOT DESCRIBES A FOUR DAY TRIP THAT FLIES THE FIRST THREE DAYS AS ALL NIGHTERS AND ENDS THE FOURTH DAY WITH A LONG MULTI-LEG DAYLIGHT FLIGHT. EXTREME FATIGUE RESULTS FROM CIRCADIAN RHYTHM EFFECTS AND LACK OF SLEEP.

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TRIP XXX; A 4-DAY TRIP STARTING LATE EVENING ON DAY 1 THROUGH DAY 3 WITH ALL-NIGHTERS EACH NIGHT. THE RPT DESCRIBES START; END; AND BLOCK TIMES FOR EACH DAY. SAME PAIRING; RPTED MANY TIMES BEFORE OVER MANY MONTHS. SAME ISSUES. UNSAFE PAIRING. OPERATES EARLY OUT OF ZZZ WITH 235 SIT IN ZZZ1 TO CIRCUMVENT ALL-NIGHT DUTY DAY RESTR IN CONTRACT. FINISHES WITH ALL-NIGHT FLT TO ZZZ2 -- HIGH ALT; HIGH TERRAIN ARPT WITH LANGUAGE BARRIER AND MULTIPLE OBSTRUCTIONS ON RWY (DOGS; RABBITS; BIRDS). DIVERT OPTIONS VERY LIMITED DUE TO LNDG WT RESTRS LIMITING FUEL LOAD AND ALTERNATES ALSO WITH MARGIN WX FORECAST. TYPICAL SCENARIO ON LIMITED REST LAYOVER IS 25 HRS. BODY CLOCK DRIVES 8 HRS SLEEP FOLLOWED BY DIFFICULTY SLEEPING FOR REST OF LAYOVER. TKOF TIME THE NEXT DAY IS TIME WHEN BODY IS READY TO GO BACK TO BED. ALL CREWS ARE FATIGUED ON RETURN WHICH IS SCHEDULED FOR AN 8 HR DAY. REALISTICALLY; IT IS OVER 9 HRS OF DUTY WHEN ALLOWING FOR CLEARING CUSTOMS IN ZZZ1 AND CHANGING PLANES TO ZZZ. CIRCADIAN RHYTHM DICTATES THAT MOST CREWS WILL BE FLYING FATIGUED WITH NO REM SLEEP IN OVER 24 HRS. DON'T FLY THIS TRIP AT THESE HRS. IF MUST BE DONE; SHOULD BE FLOWN AS A TURN OUT OF ZZZ1 SO NO CIRCADIAN SLEEP ISSUES. FATIGUE.