CL65 CREW HAD A RWY INCURSION OF RWY 25L AT MKE.

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ON MAY/FRI/03; FLT WAS PUSHED FROM GATE AT MKE; 8 MINS EARLY. MKE WX WAS RPTED AS 230 DEGS/11 KTS 9 SM SCATTERED 10000 FT; OVCST 15000 FT ALTIMETER 29.67. AS PER COMPANY POLICY; BOTH PLTS HAD MKE 10-9 ARPT DIAGRAM DISPLAYED ON MAP HOLDER. WE RECEIVED THE FOLLOWING TAXI INSTRUCTIONS: 'TAXI TO RWY 25L; VIA TXWYS B; K; AND RWY 13/31; CROSS RWYS 19L/1R; 19R/1L' AND BEGUN OUR TAXI. THIS WAS THE FIRST FLT OF THE DAY FOR THE ACFT; WHICH ALSO HAD 2 PERFORMANCE LIMITING MEL'S. DURING THE TAXI; THE CAPT WAS TAXIING; THE FO WAS RECEIVING PERFORMANCE NUMBERS FROM LOAD PLANNING; PERFORMING THE 'TAXI' AND 'BEFORE TKOF' CHKLISTS; AND DOUBLE-CHKING OUR PERFORMANCE DATA; ALONG WITH MEL LIMITATIONS. THE TAXI PROCEEDED NORMALLY ON TXWYS B AND K; AND RWY 13/31; WITH EXTREME VIGILANCE XING RWYS. AS WE APCHED THE APCH END OF RWY 31; WE WERE TOLD BY GND CTL TO STOP. GND CTL INFORMED US WE HAD TAXIED APPROX 400 FT PAST THE HOLD SHORT LINES FOR RWY 25L. IT IS IMPORTANT TO NOTE: 1) WE WERE STILL ON RWY 13/31; 2) RWY 13/31 HAS A DISPLACED THRESHOLD APPROX 500 FT FROM APCH END OF RWY 31; 3) TXWYS M; N SEPARATE RWY 31 FROM RWY 25L; 4) APPARENTLY THE 'HOLD SHORT' LINE FOR RWY 25L IS ON RWY 31 IN THE DISPLACED THRESHOLD ZONE. NO TFC CONFLICT; OR ANY OTHER ABNORMAL CONDITION OR ACTION HAPPENED AS A RESULT OF XING THE HOLD SHORT LINE. WE WERE GIVEN TKOF CLRNC; AND THE FLT PROCEEDED NORMAL; WITHOUT INCIDENT. CONTRIBUTING FACTORS: 1) NOT EXPECTING A HOLD SHORT LINE ON A SEPARATE RWY SEPARATED BY TXWYS. 2) HIGH COCKPIT WORKLOAD; RELATED TO MEL/PERFORMANCE LIMITING ITEMS. 3) NOTHING ON 10-9 CHART ; OR SURFACE CHART DISPLAY TO INDICATE ABNORMAL LOCATION OF HOLD SHORT LINES. CORRECTIVE ACTION: 1) NOTE ON 10-9 (ARPT DIAGRAM CHARTS) FOR ABNORMAL HOLD SHORT LOCATIONS. 2) A SIMPLE TAXI RTE/INSTRUCTION FROM ATC; IE...IN THE PAST NORMALLY GIVEN TAXI TO RWY 25L VIA TXWY M CROSS RWY 19R/L. SUPPLEMENTAL INFO FROM ACN 583256: ON MAY/FRI/03; FLT FROM MKE TO ORD. THE FO CONTACTED GND CTL TO TAXI. GND CTL INSTRUCTED US TO TAXI VIA TXWYS B; K; RWY 31 TO RWY 25L. ON RWY 31 WE WERE INSTRUCTED TO MONITOR THE TWR FREQ. THE FO'S HEAD WAS DOWN RUNNING THE BEFORE TKOF CHKLIST AND FIGURING OUT THE TKOF PERFORMANCE NUMBERS. THE ACFT'S ENG SPD SWITCHES; WHICH CTL ENG OVERSPD; WERE MEL'ED. THIS MEL REQUIRED THE APR (AUTOMATIC PWR RESERVE) SWITCH TO BE OFF. THIS MEL ALSO REQUIRED THE THRUST REVERSER NOT TO BE USED ABOVE 30% N1; SO MORE CONSIDERATION WAS BEING GIVEN TO ACFT TKOF PERFORMANCE. THE HOLD SHORT LINE FOR RWY 25L IS ON RWY 31. THE CAPT TAXIED ACROSS THE HOLD SHORT LINE APPROX 2 ACFT LENGTHS PAST AND STOPPED SHORT OF TXWY M; STILL ON RWY 31. THE TWR CTLR ADVISED US THAT WE HAD TAXIED PAST THE HOLD SHORT LINE. I THEN TOLD THE TWR THAT WE WERE READY FOR TKOF. ABOUT 10 SECONDS LATER HE CLRED US FOR TKOF. WE FINISHED THE BEFORE TKOF CHKLIST AND TOOK OFF WITH NO FURTHER INCIDENT. CONTRIBUTING HUMAN FACTORS WERE THE PLTS WERE NOT EXPECTING THE HOLD SHORT LINES FOR RWY 25L TO BE ON RWY 31 AND THE FO'S HEAD BEING DOWN DEALING WITH THE EXTRA PERFORMANCE CONSIDERATION DUE TO THE ENG SPD CTL SWITCHES BEING MEL'ED.