LOSS OF CABIN PRESSURE WHEN THE REMAINING PACK FAILS ON A CL65 60 NM S OF DEST ARPT OF CVG.

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DURING CLBOUT FROM 18000 FT TO 19000 FT; RECEIVED A 'CABIN ALT' CAUTION MESSAGE. AFTER THIS OCCURRED; WE REQUESTED AN IMMEDIATE DSCNT. ATC ASSIGNED 11000 FT AND LATER REQUESTED LOWER TO 10000 FT. WE COMPLIED WITH RPTS TO ATC THROUGH 17500 FT AND WAS ASSIGNED AN OFF COURSE HDG OF 270 DEGS FROM APPROX 360 DEGS N. WITHIN SECONDS OF BEGINNING DSCNT; WE RECEIVED A 'CABIN ALT' WARNING MESSAGE WITH A 'CABIN PRESSURE' AURAL MESSAGE. THE CAPT AND I EXECUTED MEMORY ITEMS AND APPROPRIATE (QRH) PROCS. AFTER STABILIZING AT 10000 FT AND COMPLETING ALL CHKLIST ITEMS; WE USED THIS TIME TO TALK TO THE FLT ATTENDANT. SHE NOTIFIED US THAT ALL PAX WERE FINE AND NEVER NOTED ANYTHING UNUSUAL. SHE ALSO STATED THAT SHE WAS FINE AND NOTICED NOTHING UNUSUAL AS WELL. SINCE NO STRUCTURAL DAMAGE WAS SUSPECTED; WE OPTED NOT TO DECLARE AN EMER. WE WERE APPROX 20 MINS S OF CVG. WE OPTED TO CONTINUE TO CVG. SINCE ALL PAX RPTED NO PROBS; WE OPTED NOT TO DEPLOY MASKS (MANUALLY) SO AS NOT TO FRIGHTEN THE PAX. THE MASKS WOULD HAVE AUTO-DEPLOYED IF THE CABIN ALT EXCEEDED 14000 FT. WE NEVER EXCEEDED 12000 FT CABIN ALT; EVEN AT OUR HIGHEST ALT OF 18000 FT MSL. LEVEL NOW AT 10000 FT; WE ATTEMPTED TO RESET OUR R PACK (ACM) WHICH HAD FALLEN OFF-LINE. OUR L PACK (ACM) WAS DEFERRED AT THE TIME PER MAINT CTL. THE R PACK WOULD NOT RESET. MAINT WAS NOTIFIED ENRTE. THE PAX WERE SPOKEN TO TWICE ABOUT OUR SIT. WE LANDED WITH NO FURTHER OCCURRENCE.