On August 12, 2022, at 1502 Alaska daylight time, a Cessna 180 airplane, N6577A, was substantially damaged when it was involved in an accident near Sutton-Alpine, Alaska. The pilot sustained minor injuries. The airplane was operated as a Title 14 Code of Federal Regulations Part 91 personal flight. The pilot reported that he departed from his home airport, Anderson Lake Airport (0AK1), Wasilla, Alaska, about 1300 with 37 gallons of fuel onboard. About two hours into the flight, while at 7,500 ft mean sea level (msl), the engine lost total power, and he assumed it was due to fuel starvation. He was unable to restart the engine and maneuvered the airplane for a forced landing in a canyon. The airplane impacted trees and brush and came to rest upright in a nose-low attitude. The pilot later reported that before the flight he had fueled the airplane from his personal 500-gallon fuel tank, and that the airplane had about three hours of fuel for the two-hour flight. The responding FAA inspectors reported that the airplane sustained substantial damage to the fuselage, both wings, vertical stabilizer, rudder, and horizontal stabilizer. Initial postaccident examination of the engine revealed no signs of a catastrophic failure or an oil leak. The throttle and mixture control linkages were intact and operational from cockpit controls to the carburetor. The main fuel line to carburetor was removed and fuel was present. The main fuel shutoff valve in the cockpit was selected from OFF to BOTH and about 2 oz of fuel drained from the main fuel line. The carburetor was removed; fuel sprayed into to the carburetor venturi when the throttle linkage was moved, which indicated that the fuel accelerator pump was operational. The fuel strainer (gascolator) was disassembled, which revealed a pink-red fuzzy material and some debris on the strainer screen. There was not enough debris to obstruct fuel flow. The fuel strainer remained undamaged and did not contain any fuel. They were unable to determine if any fuel leaked from the fuel tanks at the accident site or during the recovery, but there were signs of fuel staining on the airplane. There was minimal fuel found in the tanks during the examination. The pilot stated to the FAA that, during the emergency descent, he only accomplished a couple of [troubleshooting] items in attempt to restart the engine. The pilot could not recall if he attempted to prime the engine. He also stated to the FAA that he was low on fuel when the engine lost power. A follow-up engine examination was completed by the NTSB. The crankshaft was rotated without issue and suction and compression was obtained from each cylinder. The magnetos produced a spark at each ignition lead as the engine was rotated. The examination did not reveal any mechanical malfunctions or failures that would have precluded normal operation.