On February 15, 2023, about 1730 Pacific standard time, an unregistered Star Lite SL-1 airplane was destroyed when it was involved in an accident near Corning, California. The student pilot was fatally injured. The airplane was operated as a Title 14 Code of Federal Regulations Part 91 personal flight. The owner of the airplane stated that on the day of the accident he and the accident pilot were taking turns flying the airplane in the traffic pattern at Corning Municipal Airport (0O4). The owner performed five or six takeoffs and landings, and then switched with the accident pilot. The accident pilot flew once around the traffic pattern and landed without incident. On the second flight, the pilot took off from runway 35 and performed what the owner described as an “aerobatic” or barrel roll. He stated that the pilot appeared to pull out of the roll too slowly, while in a nose-down attitude, and that the pilot attempted an aggressive recovery. As the airplane‘s speed increased , the left wing separated, and the airplane impacted terrain. Another witness to the accident provided a statement consistent with that of the airplane owner. The airplane impacted the ground about 0.5 miles southwest of the airport. The airplane came to rest in an orchard with debris scattered throughout an approximate 90-yard radius. The left wing was located about 60 yards northwest of the main wreckage. The owner discarded the wreckage before an examination could be performed. The airplane owner stated that he had purchased the airplane three to four months before the accident. He was under the impression it was in the ultralight category, and he did not provide maintenance records. The owner stated that the airplane was not aerobatic capable. The pilot held a student pilot/third class medical certificate, issued in September 2021. At the time of the medical examination, the pilot reported 120 total hours of flight experience, with 45 hours in the previous six months. The pilot reported no medications. No pilot records were located and the pilot’s total flight experience at the time of the accident was not determined. An autopsy of the pilot was performed by Bennet Omalu Pathology, at the request of the County of Tehama Sheriff-Coroner’s Department. According to the autopsy report, the cause of death was acceleration-deceleration polytrauma. The FAA Forensic Sciences Laboratory performed toxicology testing of postmortem specimens from the pilot. Amphetamine was detected in cavity blood at 149 ng/mL and in liver tissue at 144 ng/g. Bupropion was detected in cavity blood at 40 ng/mL and in liver tissue at 38 ng/g. Hydroxybupropion was detected in cavity blood at 122 ng/mL and in liver tissue at 1345 ng/g. According to the pilot’s wife, the pilot had recently been diagnosed with bipolar disorder and was being treated for attention-deficit/hyperactivity disorder. Reviewed records contained no further details regarding the pilot’s health conditions or any associated symptoms. Amphetamine is a prescription Federal Schedule II controlled substance. Amphetamine may be prescribed for attention-deficit/hyperactivity disorder, narcolepsy, and obesity. Amphetamine usually carries a warning that the drug may impair the ability to operate a vehicle, and care should be taken until the effects of the drug are assessed after initiation of use. Amphetamine also generally carries a warning that use in individuals diagnosed with bipolar disorder without an additional medication to stabilize mood can precipitate mania. Amphetamine can be used recreationally by users seeking euphoric effects and to increase alertness and relieve fatigue. Abuse of amphetamine may lead to psychosis, paranoia, auditory and visual hallucinations. In addition to being available as a drug itself, amphetamine is a metabolite of methamphetamine, another drug in the same class. The FAA considers amphetamine or methamphetamine use disqualifying for pilot medical certification. Bupropion is a prescription medication that acts on the central nervous system (CNS) and can be used to treat depression and to help people quit smoking. Bupropion is sometimes used as part of the treatment of ADHD or of depression in bipolar disorder. Hydroxybupropion is a metabolite of bupropion. Bupropion’s mechanism of action and side-effect profile differs from other antidepressants; it does not typically cause sedation but may cause insomnia; to avoid adverse events including an increased risk of seizures, strict dosing guidelines are recommended. One small study of healthy subjects found no significant impact of sustained-release bupropion on psychomotor performance, including on tests intended to simulate flying performance. In patients with major depression, bupropion may improve associated neurocognitive deficits. Research on motor vehicle crash risk indicates that depression, antidepressants, or the combination of depression and antidepressants may present a safety hazard, but the independent contributions of antidepressants to that hazard generally are not well-defined. Typically, bupropion carries a warning that any drug that acts on the CNS may impair users' ability to perform tasks requiring judgment or motor and cognitive skills, and that bupropion users should not drive or operate hazardous machinery until they are reasonably certain that the drug does not adversely affect their performance. Bupropion also generally carries a warning that use in individuals with bipolar disorder without an additional medication to stabilize mood, can precipitate mania. At the time of this accident and the final FAA medical case review for this accident, bupropion use was unacceptable for pilots.