PLT OF A PART 135 CARGO C208 DEPARTED DRO OFF RWY 20 WITH DOWNHILL SLOPE MAY HAVE OFFENDED THE PLT OF A PA28 IN THE PATTERN FOR RWY 2.

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DRO RWY 20 AND RWY 2. RWY 20 HAS A DOWNHILL GRADE OF ABOUT 1%. WINDS CALM; WX CAVU. DEPARTING WITH NIGHTLY SCHEDULED C208 FREIGHT FLT AT MAX GROSS WT. PA24 HAD JUST DEPARTED RWY 2 AND WAS MAKING L XWIND. PA28 CALLING HIMSELF 'WARRIOR N (UNKNOWN)' RPTED L DOWNWIND FOR RWY 2. I CALLED THAT I WAS DEPARTING RWY 20 AND THAT I HAD THE 'CHEROKEE' IN SIGHT. I EXPEDITED THE L XWIND TURN AND WAS HDG PERPENDICULAR TO THE RWY CTRLINE PRIOR TO SEEING ANY TURN BY THE PA28. AT THAT TIME; I SAW HIM TURN R OUT OF THE DOWNWIND. ABOUT 15 SECONDS LATER I HEARD HIM XMIT SOMETHING LIKE HE WAS EXITING THE PATTERN AND WAS GOING TO RE-ENTER BECAUSE HE HAD AN AIRPLANE RIGHT IN HIS FACE. ON REFLECTION; I BELIEVE THAT THE PA28 MAY HAVE NOT HEARD MY XMISSION OR HE CHOSE TO IGNORE IT BECAUSE HE WAS ANNOYED THAT I WAS USING THE RWY OPPOSITE TO HIM. HE DOES NOT REALIZE THAT THE DOWNHILL SLOPE MAKES A SIGNIFICANT DIFFERENCE TO A HEAVILY LOADED ACFT ON TKOF. ADDITIONALLY; TKOF ON RWY 2 FULL LENGTH REQUIRES A BACK TAXI ON THE ACTIVE BECAUSE THE PARALLEL DOES NOT CONTINUE ALL THE WAY TO THE END. I HAD HIS ACFT IN SIGHT AT ALL TIMES AND THE NEAREST WE APCHED WAS ABOUT 1 MI. HE NEVER DID TURN A BASE LEG AND I IMMEDIATELY TURNED XWIND OFF OF RWY 20 SO OUR PATHS WERE ALWAYS PARALLEL OR DIVERGING. I HAVE PREVIOUSLY COORDINATED EXPEDITED DEPS FOR MYSELF WITH ACFT THAT ARE IN THE PATTERN AT DRO. OFTEN TIMES IT'S OTHER PROFESSIONALLY OPERATED ACFT. IT WAS NEVER A PROB BEFORE. THE MORE SENIOR PLTS PERHAPS ARE BETTER JUDGES WHEN IT COMES TO DETERMINING THE RISK OF A MIDAIR WHEN THEY SEE OTHER ACFT INFLT. ANOTHER FACTOR; I ALWAYS RECEIVED AN ACKNOWLEDGEMENT BEFORE. THIS TIME I DID NOT. PERHAPS THAT WAS MY ERROR.