A G3 AND A TWIN BEECH ALMOST COLLIDE WHEN THE G3 TAXIES ONTO RWY 25R AS THE BE18 WAS ROLLING ON SAME RWY AT MKE; WI.

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RWY 25L&R WERE ACTIVE. TWIN BEECH WAS TAXIED TO RWY 25R FOR DEP. GULFSTREAM CALLED GND CTL FOR TAXI. GND CTLR INSTRUCTED G3 TO TAXI TO RWY 25L VIA TXWY F AND TXWY E; HOLD SHORT OF RWY 25R. G3 READ BACK CORRECT TAXI RTE AND HOLD SHORT OF RWY 25R. A SHORT TIME LATER THE G3 CALLED GND CTL TO VERIFY TAXI VIA TXWY F; TXWY H; TXWY K. GND CTLR VERIFIED HIS POS ON THE FIELD; AND AGAIN VERY EXPLICITLY ISSUED TAXI INSTRUCTIONS. THE G3 ACKNOWLEDGED AND TAXIED VIA TXWY F AND TXWY Z (NOT CORRECT). THE TWIN BEECH WAS CLRED FOR TKOF ON RWY 25R AS GND CTLR OBSERVED THE G3 ENCROACHING THE RWY. GND CTLR INSTRUCTED THE G3 TO HOLD SHORT OF RWY 25R 'IT'S THE NEXT INTXN.' GND CTLR RECEIVED NO RESPONSE. GND CTLR WENT BACK AND TOLD THE G3 TO STOP! THE G3 CONTINUED TO ROLL FINALLY COMING TO A STOP ON RWY 25R. THE TWIN BEECH TOOK EVASIVE ACTION TO MISS THE G3. POSSIBLE CAUSES: CONFUSION FROM THE GET GO ON THE PART OF THE G3 PLT. THERE WAS A CHK RIDE GOING ON IN THE G3. MAYBE THEY WERE BUSY WITH OTHER THINGS. GND CTLR COULD HAVE REITERATED THE HOLD SHORT INSTRUCTION WHEN ISSUING EXPLICIT TAXI INSTRUCTIONS. THE G3 PLT COULD HAVE BECOME CONFUSED WHEN HE WRONGLY TAXIED ON TXWY Z. BY TAXIING ON TXWY Z THE INTXN NEAR RWY 25R IS CONFUSING. A LOT OF CONCRETE COMES TOGETHER AT THAT POINT. NOT LISTENING WAS A PROB.