B757 FLT CREW HAS WRONG 'DIRECT TO' FIX INSTALLED IN THE FMS AND THE ACFT TURNS THE WRONG WAY ON THE KENNEDY 9 DEP.

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CLBING THROUGH 9000 FT MSL ON A RADAR VECTOR DEPARTING JFK (185 DEG HDG); WE WERE CLRED DIRECT RBV VOR. WHEN RBV WAS SELECTED AND EXECUTED ON THE FMS; ACFT TURNED IN A DIRECTION OPPOSITE THE PROPER COURSE TO RBV. THE ACFT FMS WAS ACTUALLY SEEKING A NAVAID CALLED 'RBV' THAT WAS APPROX 7000 MI AWAY! THIS MAY HAVE BEEN AN INITIAL PROGRAMMING ERROR IN THE FMS; BUT I DON'T THINK SO. I BELIEVE THE PROPER 'RBV' WAS SELECTED; BUT FOR SOME REASON; THE IMPROPER 'RBV' ENDED UP IN THE COMPUTER. NO 'INSUFFICIENT FUEL' MESSAGE EVER DISPLAYED IN THE PREFLT OR AT ANY TIME PRIOR TO THE INCIDENT; AS WOULD NORMALLY OCCUR IN THIS CIRCUMSTANCE. LESSON LEARNED: ON DEP; ALWAYS BACK UP THE FMS WITH RAW DATA IF NOT THOROUGHLY FAMILIAR WITH THE AREA AND ALL SURROUNDING NAVAIDS. CONTRIBUTING FACTORS: RWY CHANGE DURING PUSHBACK; MAINT ISSUE PRIOR TO PUSHBACK WHICH DISTR FROM THE NORMAL FLOW; FATIGUE -- EARLY DEP; LAST DAY OF 3-DAY TRIP; BODY CLOCKS ON MOUNTAIN TIME ZONE. SUPPLEMENTAL INFO FROM ACN 703593: IT WOULD HAVE HELPED TO HAVE THE NAVAID BUTTON ACTIVE AND FIRST FIX IN THE 'FIX' PAGE FOR BETTER SITUATIONAL AWARENESS. CALLBACK CONVERSATION WITH RPTR ACN #703592 REVEALED THE FOLLOWING INFO: RPTR STATED THAT DURING PREFLT THEY HAD LOADED RBV AS PART OF THE DEP/CLRNC. THERE WAS NO 'INSUFFICIENT FUEL' MESSAGE WHICH WOULD HAVE INDICATED THAT THE FIX WAS TOO FAR AWAY FOR THE FUEL LOAD ON THE ACFT. HE STATED THAT AFTER DEP THE CTLR CLRED THE ACFT DIRECT TO RBV AND WHEN SELECTED AS 'DIRECT TO' IN THE FMS THE ACFT TURNED THE WRONG WAY AND THE CTLR ASKED 'WHERE THEY WERE GOING.' AT THIS TIME THEY REALIZED THAT THERE WAS SOMETHING WRONG AND ASKED FOR VECTORS FROM THE CTLR. AFTER TUNING IN THE FREQ AND GOING TO RAW DATA THEY FINALLY REALIZED WHERE THEY WERE AND CORRECTED THE FMS. THE RPTR INDICATED THAT THEY WERE RUSHED DUE TO A RWY CHANGE AND THAT THEY HAD NOT REVIEWED THE LEGS PAGE FOR FIX/DISTANCES OR THE TOTAL DISTANCE FOR THE RTE OF FLT. THEY DID NOT HAVE RAW DATA TUNED AND AVAILABLE PRIOR TO DEP AND HE INDICATED THAT THAT WAS THEIR MISTAKE AS THE DEP CAME VERY FAST AND THE FLT CREW WAS NOT FAMILIAR WITH THE AREA OR CHART AS THEY SHOULD HAVE BEEN. HE ALSO STATED THAT THEY MAY HAVE BEEN SLIGHTLY FATIGUED DUE TO LACK OF PROPER REST.