AN A320 CAPT CANCELLED A F/CTL SPLR FAULT ECAM DURING ENG START BECAUSE IT WAS A PRESUMED NUANCE FAULT WITH A SPOILER MEL'ED. IN FLT AN ADDITIONAL SPOILER WAS FOUND INOP WITH NO APPARENT WARNING.

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I ACCEPTED AN ACFT WITH THE #4 SPOILER INOP AND DEFERRED. AFTER REVIEWING THE MEL AND APPLYING ALL TKOF PENALTY WE PROCEEDED TO PUSH BACK FOR DEP. DURING ENG START THE F/CTL SPLR FAULT ECAM ILLUMINATED SEVERAL TIMES AS PWR SOURCES SWITCHED. THE ECAM WAS CANCELED BY ME AND JUDGED AS A 'NUISANCE ECAM' DUE TO THE DEFERRED SPOILER SYS. IN CRUISE; WHILE COMPUTING THE LNDG DISTANCE ABNORMAL CONFIGN IN PREPARATION FOR LNDG; THE FO AND I NOTICED THAT SPOILER PANEL #1 WAS NOW INOP AS WELL; INDICATED BY AMBER X'S ON THE ECAM FLT CTLS PAGE. WE DISCUSSED WHEN THESE SPOILERS BECAME INOP AS WE HAD NO ABNORMAL INDICATIONS DURING THE FLT. APPROPRIATE CORRECTIONS WERE TAKEN FOR LNDG PERFORMANCE AND A NORMAL LNDG MADE AT THE DEST. OUR RECOLLECTION OF THE FLT CTL CHK MADE BEFORE DEP WAS THAT ALL WAS 'NORMAL' WITH THE EXCEPTION OF THE DEFERRED SPOILERS. DEST MAINT PERSONNEL WERE ABLE TO REGAIN SPOILER #1 NORMAL FUNCTION BY RESETTING SEC 3. WHILE I AM STILL UNSURE OF EXACTLY WHEN SPOILER #1 BECAME INOP; I TAKE AWAY FROM THIS THAT EVERY ECAM SHOULD BE THOROUGHLY INVESTIGATED. DEFERRED SYS NEED EXTRA ATTN TO MAKE SURE THE SYS IS OPERATING AS DESCRIBED ON THE DEFERRAL ITEM AND HAVE NOT DEGRADED FURTHER.