The 15,600 hour commercial rated pilot was initiating the first aerial application flight of the day and decided to make the takeoff with a full fuel load and full hopper of chemicals on an upslope runway. The airplane was not able to establish an initial climb and began to settle back to the ground. The pilot attempted to dump the chemical load but was unsuccessful and the airplane impacted the ground and cart wheeled, coming to rest in the upright position. The pilot was not injured and was able to exit the aircraft unassisted. The airplane sustained substantial damage to the wings, landing gear, engine case, propellers, and empennage. Weather reported at the time of the accident was winds 340 degrees at 23 knots gusting to 28 knots.